Effects and Safety of Caspofungin and Corticosteroids in Pneumocystis Pneumonia in Non-HIV Patients

Capital Medical University

Status: Unknown

Conditions: Pneumocystis Pneumonia

Treatments: Drug: corticosteroids; Drug: Sulfanilamides; Drug: caspofungin

Study type: Interventional

Funder types: Other

Identifiers

NCT02603575

BeijingCYHRICU01

Details and patient eligibility

About

Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population. All Immunocompromised Non-HIV patients with respiratory failure were randomized into caspofungin and non-caspofungin group and corticosteroids and non-steroids group. The major outcome is 28 day mortality, the second outcome are time of respiratory rate decreases to less than 25 breath per minute, body temperature lower than 37.3℃.

Enrollment: 60 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Immunocompromised Non-HIV Infected Patients
• Partial arterial O2 pressure(PaO2)/FiO2≤300mmHg
• Diagnosed as Pneumocystis Pneumonia

Exclusion criteria

• younger than 16 years old
• severe organ failure
• allergic to sulfanilamide, caspofungin or corticosteroid

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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60 participants in 4 patient groups

Caspofungin and corticosteroids

Experimental group

Description:

patients treat with caspofungin and corticosteroids on the base of sulfanilamide

Treatment:

Drug: caspofungin

Drug: Sulfanilamides

Drug: corticosteroids

Caspofungin and no corticosteroids

Active Comparator group

Description:

patients treat with caspofungin on the base of sulfanilamide

Treatment:

Drug: caspofungin

Drug: Sulfanilamides

corticosteroids and no caspofungin

Active Comparator group

Description:

patients treat with corticosteroids on the base of sulfanilamide

Treatment:

Drug: Sulfanilamides

Drug: corticosteroids

no corticosteroids and no caspofungin

Active Comparator group

Description:

patients treat with sulfanilamide only

Treatment:

Drug: Sulfanilamides