Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

Tangshan Maternal and Child Health Hospital

Status: Completed

Conditions: Gynecological Laparoscopic Surgery; General Anesthetic; Intubation

Treatments: Drug: Sufentanil; Drug: Oliceridine

Study type: Interventional

Funder types: Other

Identifiers

NCT07372209

2024-074-01

Details and patient eligibility

About

to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil

Enrollment: 120 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 18-65 years;
2. American Society of Anesthesiologists (ASA) physical status I-II;
3. Elective gynecologic laparoscopic surgery;
4. Expected operative time 60-180 minutes;

Exclusion criteria

1. Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia);
2. Uncontrolled hypertension;
3. Severe renal or hepatic dysfunction;
4. Severe mental disorder or psychiatric illness;
5. Known allergy or hypersensitivity to opioids;
6. History of alcohol abuse or opioid addiction;
7. Anticipated difficult airway;
8. Pregnancy or lactation;

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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120 participants in 2 patient groups

sufentanil

Active Comparator group

Description:

0.5μg/kg of sufentanil was used for anesthesia induction

Treatment:

Drug: Sufentanil

Oliceridine

Experimental group

Description:

0.13mg/kg oliceridine was used for anesthesia induction

Treatment:

Drug: Oliceridine