Effects of 3 Months of Supervised Exercise Training

University Hospital, Clermont-Ferrand

Status

Unknown

Conditions

Overweight/Obesity

Sedentarity

Type 2 Diabetes

Glucose Intolerance

Treatments

Behavioral: Behavior: Supervised physical training

Study type

Interventional

Funder types

Other

Identifiers

NCT01349166

CHU-0088

Details and patient eligibility

About

The incidence of type 2 diabetes is increasing worldwide. Because of cardiovascular morbidity and mortality associated with type 2 diabetes, it is imperative to propose methods of prevention and this in early stage of abnormal glucose metabolism.

This study will assess the beneficial effects of physical activity (acute and chronic effects) (the subjects being their own controls) on cardiometabolic and inflammatory biomarkers in 3 conditions : unstimulated (fasting and resting conditions) and stimulated conditions: postprandial response to a standardized meal preceded or not by an exercise bout.

The investigators hypothesized that an acute bout of exercise will decrease the postprandial inflammatory response to a standardized meal and that this effect of exercise will be increased after 3 months of exercise training.

Full description

This is a prospective study over 4 months, open, nonrandomized. 45 overweight or obese male subjects will complete 3 experimental sessions (0700-1400h) before and after 3 months of supervised physical training. During a first session, subjects will remain inactive and fasted (basal conditions). During the second session a standardized meal will be offered (postprandial response to a standardized meal). The third session will consist in the realization of an exercise bout (60min at 60%VO2 max) followed by a standardized meal (same meal that the previous day).

Several blood (catheter), salivary and urinary samples will be collected during the 3 sessions, throughout the experimental day.

Enrollment

45 estimated patients

Sex

Male

Ages

30 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male Caucasian Adults between 30 and 65 years old Sedentary criteria based on the determination of fasting glucose (WHO 1999):
normal if fasting plasma glucose (FPG) <1.10 g / l
diabetes if fasting glucose> 1.26 g / l (7 mmol / l) twice
nondiabetic fasting hyperglycemia: 1.10 g / l ≤ FPG ≤ 1.26 g / l
glucose intolerance : if plasma glucose at 120 minutes during the OGTT (75g) is between 1.40 g / l and 2 g/ l.

Body mass index 25 BMI 35kg/m2 Affiliated to National Health Insurance Subject giving his written informed consent Subject considered as normal after clinical examination and medical questionnaire

Exclusion criteria

- drugs that interfere with the parameters determined
diabetic treated with insulin, glitazones or glinides
eating disorders like bulimia and vomiting
special diet, vegan or vegetarian
autoimmune disease or inflammatory progressive desease requiring prolonged treatment
regular physical activity (> 1 hour of physical activity per week for at least 6 months)
smoking (> 5 cigarettes / day)
weight change greater than 5% of the total weight in the 3 months preceding the study
contra-indication to physical activity
chronic pathologies: cancer, inflammatory, cardiac, pulmonary, renal, gastrointestinal or liver diseases
Being in exclusion on the National Volunteers Data file
No one under guardianship or not subject to social security.
Being under someone's supervision
Subjects deprived of their liberty by judicial or administrative.
Refusal to sign the information sheet and written consent for particip