Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis

University of Verona

Status: Completed

Conditions: Cystic Fibrosis

Treatments: Dietary Supplement: 5-methyltetrahydrofolate and vitamin B12

Study type: Interventional

Funder types: Other

Identifiers

NCT00730509

UNIVR_REUM_01

Details and patient eligibility

About

The purpose of this study is to determine whether 5 - methyltetrahydrofolate and vitamin B12 supplementation can ameliorate cell plasma membrane features in pediatric patients with cystic fibrosis

Full description

Cystic fibrosis (CF) is one of the most common fatal autosomal recessive disorders in the Caucasian population caused by mutations of gene for the cystic fibrosis transmembrane conductance regulator (CFTR). New experimental therapeutic strategies for CF propose a diet supplementation to affect the plasma membrane fluidity and to modulate the cellular amplified inflammatory response in CF target organs. Red blood cells (RBCs) were used to investigate plasma membrane, because RBCs share lipid, protein composition and organization with other cell types.

Enrollment: 31 patients

Sex: All

Ages: 3 to 8 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• cystic fibrosis

Exclusion criteria

• diabetes
• chronic infections of the airways
• regular antibiotics intake