Effects of a Beverage Rich in Fruit Extracts on Risk Factors Associated With Cardiovascular Disease

University of Glasgow

Status: Unknown

Conditions: Cardiovascular Disease

Treatments: Dietary Supplement: High polyphenol beverage; Dietary Supplement: Placebo Beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT00795834

07/S0704/110

RN08BI013

Details and patient eligibility

About

The purpose of this study is to assess the effects of a novel beverage rich in polyphenols (compounds present in fruit extracts) on risk factors associated with cardiovascular disease.

Full description

This study will assess the potential of a beverage containing plant and fruit extracts rich in polyphenolics to modulate vascular risk.

Novel risk factors for vascular disease will be assessed including non-invasive assessment of vascular function by pulse wave analysis / pulse wave velocity and laser doppler iontophoresis.

Enrollment: 40 estimated patients

Sex: All

Ages: 55+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >/= 55 years
• BMI > 25

Exclusion criteria

• Present smoker or smoked within the last 2 years
• HBA1C > 6.0%
• eGFR<60
• LFT >/= 3 times upper limit of normal
• Hypertension: systolic blood pressure > 160mmHg; diastolic blood pressure > 90mmHg, or on medication for hypertension.
• Chronic disease, likely to be clinically relevant (eg:

cardiorespiratory, rheumatological, cerebrovascular or neoplastic disease)

• Vitamin supplements within the previous 14 days
• Medications which, in the opinion of the investigators, are known to influence vascular function (eg corticosteroids).

Trial design

40 participants in 2 patient groups, including a placebo group

Beverage

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo Beverage

High Polyphenol Beverage

Active Comparator group

Treatment:

Dietary Supplement: High polyphenol beverage