Effects of a Chewing Gum Containing POs-Ca and Fluoride on Enamel

Tokyo Medical and Dental University

Status and phase: Completed; Early Phase 1

Conditions: Enamel Subsurface Lesion

Treatments: Dietary Supplement: chewing gum

Study type: Interventional

Funder types: Other

Identifiers

NCT01377493

1B116

Details and patient eligibility

About

There were no differences in the degree of enamel remineralization of subsurface lesions among the chewing gums containing or not containing POs-Ca and fluoride.

Enrollment: 36 patients

Sex: All

Ages: 20 to 31 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adult subjects
• More than 22 permanent teeth

Exclusion criteria

• Alcohol addiction
• Smoking
• Active caries
• Periodontal pockets
• Low-saliva flow (less than 0.3ml/min)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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36 participants in 3 patient groups, including a placebo group

placebo

Placebo Comparator group

Treatment:

Dietary Supplement: chewing gum

POs-Ca

Active Comparator group

Treatment:

Dietary Supplement: chewing gum

POs-Ca+F

Active Comparator group

Treatment:

Dietary Supplement: chewing gum