Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD

National Institute of Respiratory Diseases (INER)

Status: Unknown

Conditions: Samter's Syndrome; Aspirin-exacerbated Respiratory Disease; Aspirin-Sensitive Asthma With Nasal Polyps; Widal Syndrome

Treatments: Other: Low salycilate diet

Study type: Interventional

Funder types: Other

Identifiers

NCT03973749

C13-17

Details and patient eligibility

About

On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting. Group 1 will recieve a low-salycilate diet, and group 2 a high-salycilate diet. Two hours after each meal, urinary Leucotriene E4, FEV1, FVC, FEV1/FVC and total nasal resistance will be measured. On day 7, after clearance time, group 1 will recieve high-salycilate diet and group 2 low salycilate diet and the same measurements will be obtained.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed Aspirin exacerbated respiratory disease.
• Controled asthma
• No actual systemic corticosteroid treatment
• No antileucotriene treatment.

Exclusion criteria

• Patients who do not complete both phases of the study
• Patients unable to perform adecuate spyrometric testing
• Patients who present severe asthmatic reactions with high salycilate foods

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Group 1

Experimental group

Description:

Low salycilate diet on day one and High salycilate diet on day 7

Treatment:

Other: Low salycilate diet

Group 2

Experimental group

Description:

High salycilate diet on day one and Low salycilate diet on day 7

Treatment:

Other: Low salycilate diet