Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects

Azienda Ospedaliero, Universitaria Pisana

Status

Completed

Conditions

Lipids

Treatments

Dietary Supplement: Low fat/cholesterol diet

Dietary Supplement: High fat/cholesterol diet

Study type

Interventional

Funder types

Other

Identifiers

NCT02549144

HDL-DIET

Details and patient eligibility

About

In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week low-fat/low-cholesterol (LFLC) normocaloric diet.

Full description

HDL particles can change their composition and function in response to a variety of pathological conditions and environmental stimuli. It has been previously shown that a western diet is able to drastically modify biochemical composition, anti-inflammatory and anti-oxidant properties of HDL in animals. In humans little is known on the role of diet on HDL function and composition.

Enrollment

14 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subjects ≥ 18 and ≤40 years of age
Lean or overweight (BMI: 18 to 29,9 kg/m2)
Normal liver and kidney function
Normal thyroid function
Stable weight in the last 3 months
Read and understood the informed consent form and signed it voluntarily

Exclusion criteria

Liver, heart, kidney, lung, infectious, neurological, psychiatric, endocrine, immunological or neoplastic diseases
Chronic use of drugs or vitamin supplements
Smoking
Pregnancy or lactation