Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism. (KS-4-HypoPT)

University of Copenhagen

Status: Completed

Conditions: Hypoparathyroidism

Treatments: Other: Placebo (saline); Other: GIP; Other: Liquid meal (Nutridrink); Other: GLP-2

Study type: Interventional

Funder types: Other

Identifiers

NCT03728959

KS-4-HypoPT

Details and patient eligibility

About

Hypoparathyroidism (hypoPT) is characterized by low levels of PTH.

In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.

Enrollment: 7 patients

Sex: All

Ages: 18 to 76 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 76
• Hypoparathyroidism

Exclusion criteria

• Diabetes
• Disease in the gastrointestinal tract
• Antiosteoporotic drug
• Long term steroid treatment (within the last 12 months)
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

7 participants in 4 patient groups

Liquid meal (Nutridrink)

Experimental group

Description:

Liquid meal (Nutridrink)

Treatment:

Other: Liquid meal (Nutridrink)

GIP

Experimental group

Description:

Glucose-dependent insulinotropic polypeptide

Treatment:

Other: GIP

GLP-2

Experimental group

Description:

Glucagon-like peptide-2

Treatment:

Other: GLP-2

Placebo (saline)

Experimental group

Description:

Placebo (saline)

Treatment:

Other: Placebo (saline)