Effects of a Multiple Component Training Program on Muscles in Adults With Myotonic Dystrophy Type 1

Cynthia Gagnon

Status: Completed

Conditions: Myotonic Dystrophy 1

Treatments: Other: Training program

Study type: Interventional

Funder types: Other

Identifiers

NCT04001920

2013-008

Details and patient eligibility

About

A strength and endurance training program was conducted in adults with myotonic dystrophy type 1 (DM1). Participants underwent a 12-week/18-session supervised training program consisted of 6 exercises: elbow flexion/extension, shoulder horizontal adduction, leg press, and knee flexion/extension. To offer a complete training program aimed at improving function it was divided: the first 6 weeks were dedicated to strength-training, whereas the following weeks focused on endurance-training. To evaluate the effects of the training program, participants completed maximal strength, endurance and functional evaluations. Volunteers could also add a muscle biopsy at the beginning and the end of the program to evaluate physiological parameters.

Enrollment: 11 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with DM1
• Walk without technical aid
• Muscle impairment rating scale (MIRS) of 3 or 4

Exclusion criteria

• Severe musculoskeletal disorders
• Any medical contraindication to physical exercise
• Any medical contraindication to muscle biopsies for the biopsy volunteers

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

11 participants in 1 patient group

Training program

Experimental group

Description:

12-week strength and endurance training program

Treatment:

Other: Training program