Effects of a Pre-Workout Dietary Supplement on Training Adaptations (NB2)

Texas A&M University

Status: Completed

Conditions: Dietary Modification

Treatments: Dietary Supplement: C4 Extreme, C4 Extreme (without Advantra Z)

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02999581

IRB2014-0079FX

Details and patient eligibility

About

The purpose of this study is to examine the effects of a pre-workout dietary supplement during resistance training on training adaptations.

Full description

A number of nutritional strategies have been developed to optimize nutrient delivery prior to exercise. This includes providing carbohydrate and a number of ergogenic nutrients prior to, during and/or following exercise. As a result, a number of pre-workout supplements have been developed to increase energy availability, promote vasodilation and/or positively affect exercise capacity. The purpose of this study is to investigate the effects of ingesting a pre-workout dietary supplement during resistance training on training adaptations.

Enrollment: 122 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• you are an apparently healthy and recreationally active male between the ages of 18 and 40.
• you will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat.

Exclusion criteria

• you have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmia and/or cardiovascular disease;
• you are currently using prescription medications;
• you have an intolerance to caffeine and/or other natural stimulants;
• you have a history of smoking;
• you drink excessively (i.e., 12 drinks per week or more);

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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122 participants in 3 patient groups, including a placebo group

C4 Extreme

Experimental group

Description:

One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 10 mg Bitter Orange (Citrus Aurantium) fruit standardized for 30% synephrine (Advantra Z), 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.

Treatment:

Dietary Supplement: C4 Extreme, C4 Extreme (without Advantra Z)

C4 Extreme (without Advantra Z)

Active Comparator group

Description:

One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.

Treatment:

Dietary Supplement: C4 Extreme, C4 Extreme (without Advantra Z)

Placebo

Placebo Comparator group

Description:

One dose of flavored placebo (powder mixed with water)

Treatment:

Dietary Supplement: C4 Extreme, C4 Extreme (without Advantra Z)