Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors

U

University Hospital Birmingham NHS Foundation Trust

Status

Completed

Conditions

Chronic Kidney Disease

Study type

Observational

Funder types

Other

Identifiers

NCT01028703
RKK3922

Details and patient eligibility

About

Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death. This may be because kidney disease causes stiffening of the arteries in the body which means that the heart and brain are damaged by high blood pressure. By studying patients before and after the removal of a kidney (uni-nephrectomy) for transplantation the investigators will find out for the first time in man the effect of an isolated reduction in kidney function on the structure and function of the arteries and heart. Hypotheses. An isolated reduction in GFR occuring after surgical uni-nephrectomy is associated with long term adverse cardiac and vascular effects which include: Increased arterial stiffness and left ventricular mass Abnormalities in left ventricular systolic and diastolic function Increased oxidative stress, inflammation and collagen turnover

Enrollment

124 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Potential kidney donor attending University Hospital Birmingham NHS Foundation Trust

Current nationally set Exclusion Criteria:

  • Diabetes mellitus
  • Atrial fibrillation
  • Left ventricular dysfunction (ejection fraction <40% on transthoracic echocardiography)
  • History of cardiovascular or pulmonary disease
  • Evidence of hypertensive end-organ damage.

Trial design

124 participants in 2 patient groups

Donors
Description:
110 will be "cases" that undergo uninephrectomy
Controls
Description:
110 "controls"

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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