Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms

YAU Suk Yu Sonata

Status: Completed

Conditions: Depression Symptoms; Anxiety Symptoms; Healthy

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06736067

HSEARS20221111001-01

Details and patient eligibility

About

This study investigates whether a single session of aerobic exercise (like running) can improve the participants' mood and whether such benefits can be explained by changes in the blood factors (like hormones) and brain activity.

The main questions this study aims to answer are:

• Can a single session of aerobic exercise improve mood?
• Which changes in the blood and brain could explain the effects of exercise on mood?

Researchers will compare the participants' mood states before and after exercise to see whether exercise can improve mood.

The participants will:

• Answer questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) before exercise.
• Perform 30 minutes of running on a treadmill.
• Answer the same questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) after exercise.

The entire assessment will last for about 2h45min and will be performed on a single day.

Enrollment: 40 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects within the stipulated age range

Exclusion criteria

• Acute injury or illness that impairs the ability to safely exercise and/or inability to exercise with a moderate intensity;
• Metabolic and/or neurologic disorders;
• Iron implants;
• People who cannot stay still, are intolerant of noise or fearful of enclosed spaces (due to the small space inside the scanner).

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Moderate-intensity aerobic exercise

Experimental group

Description:

Thirty minutes of exercise on a treadmill, including a 5-minute warm-up followed by increments in speed until reaching optimal moderate to high intensity (60-80% of age-predicted maximal heart rate), which will be maintained for 20 min, followed by a 5-minute cool-down. Age-predicted maximal HR will be defined as 220 beats-per-minute (BPM) minus age in years.

Treatment:

Behavioral: Exercise