Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

Centro Cardiologico Monzino

Status and phase: Completed; Phase 4

Conditions: Chronic Heart Failure

Treatments: Drug: acetazolamide

Study type: Interventional

Funder types: Other

Identifiers

NCT00517426

R77-CCM S79/407

Details and patient eligibility

About

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure.

Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic heart failure in stable clinical condition
• exercise-induced periodic breathing

Exclusion criteria

• comorbidities
• NYHA class IV

Trial design

20 participants in 1 patient group

Active Acetazolamide

Experimental group

Treatment:

Drug: acetazolamide