Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

California Baptist University

Status: Completed

Conditions: Dietary Supplementation

Treatments: Dietary Supplement: Grape seed extract

Study type: Interventional

Funder types: Other

Identifiers

NCT05945771

107-2122-EXP

Details and patient eligibility

About

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Enrollment: 12 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion criteria

• cardiovascular and/or pulmonary disease,
• musculoskeletal disorders
• medications that prevent the safe completion of the exercise protocol

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups, including a placebo group

Randomized double blind grape seed extract design

Active Comparator group

Description:

Grape seed extract

Treatment:

Dietary Supplement: Grape seed extract

Control

Placebo Comparator group

Description:

Placebo (starch)

Treatment:

Dietary Supplement: Grape seed extract