Effects of Acutely Elevated Afterload on Left Ventricular Contractility and Relaxation (ANREP-EF)

University of Luebeck

Status: Terminated

Conditions: Heart Failure

Treatments: Device: Conductance catheter

Study type: Interventional

Funder types: Other

Identifiers

NCT02751853

16-011

Details and patient eligibility

About

Aim of the study is to assess the effects of abruptly increased afterload on left ventricular contractility and relaxation in patients with heart failure with preserved ejection fraction (HFPEF), patients with heart failure with reduced ejection fraction (HFREF), and patients without HFPEF or HFREF.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical indication for left and right heart catheterization
• HFPEF (Group 1) OR HFREF (Group 2) OR absent echocardiographic evidence of HFREF OR HFPEF(Group 3)

AND

• Sinus rhythm during invasive measurements
• Age ≥18 years
• Negative pregnancy test in women with childbearing potential
• Written informed consent

Exclusion criteria

• Acute coronary syndrome
• Acute myocardial infarction <6 months
• Planned cardiac surgery or cardiovascular intervention within 6 months following inclusion
• Valvular heart disease >2°
• Severe comorbidities with limited life expectancy <12 months
• Precapillary pulmonary hypertension
• Participation in another trial

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

HFPEF

Experimental group

Description:

Patient with heart failure with preserved ejection fraction (HFPEF)

Treatment:

Device: Conductance catheter

HFREF

Experimental group

Description:

Patient with heart failure with reduced ejection fraction (HFREF)

Treatment:

Device: Conductance catheter

No HFPEF/HFREF

Active Comparator group

Description:

Patient without heart failure with preserved ejection fraction (HFPEF) or heart failure with reduced ejection fraction (HFREF)

Treatment:

Device: Conductance catheter