Effects of AD on VI in Patients With CF

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Enrolling

Conditions: Cystic Fibrosis

Treatments: Other: Autogenic drainage; Drug: Aerosoltherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03655249

2018/22FEV/079

Details and patient eligibility

About

This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome

Full description

This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis.

Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.

Enrollment: 30 estimated patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cystic fibrosis diagnosis
• FEV1 > 40%
• Able to sustain 30min of chest physiotherapy

Exclusion criteria

• Presence of Burkoldheria cepacia or non tuberculous mycobacteria
• Orthopedic, neuromuscular or cardiac disorder likely to impact respiratory system
• Need for supplemental oxygen
• Cardiac pacemaker or internal cardiac defibrillator

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Asl + CPT

Experimental group

Description:

Aerosotherapy + Autogenic drainage

Treatment:

Drug: Aerosoltherapy

Other: Autogenic drainage

Asl

Active Comparator group

Description:

Aerosoltherapy alone

Treatment:

Drug: Aerosoltherapy