Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

University Hospital, Rouen

Status: Completed

Conditions: Anorexia Nervosa

Treatments: Other: physical activity program (APA)

Study type: Interventional

Funder types: Other

Identifiers

NCT04817436

2017/0383/HP

Details and patient eligibility

About

Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.

Enrollment: 9 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Female
2. Patient > 18 years
3. Follow-up in the department of clinical Nutrition of Rouen
4. BMI ≥15,0 and <18,5 kg/m²
5. Diagnosis of anorexia nervosa according to DSM-V classification

Exclusion criteria

1. Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension
2. Patients with poor understanding of spoken or written French
3. Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults
4. Person subject to a safeguard of justice, guardianship or curatorship.
5. Pregnant or breastfeeding woman

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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9 participants in 2 patient groups

Without adapted physical activity program (APA)

Active Comparator group

Treatment:

Other: physical activity program (APA)

With adapted physical activity program (APA)

Experimental group

Treatment:

Other: physical activity program (APA)