Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery

Isfahan University of Medical Sciences

Status and phase: Completed; Phase 4

Conditions: Lumbar Spine Disc Herniation

Treatments: Procedure: Spinal Anesthesia; Drug: Fentanyl; Drug: Magnesium Sulfate; Drug: Bupivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01843296

392022

Details and patient eligibility

About

The purpose of this study is to Compare three methods of intrathecal bupivacaine; bupivacaine-fentanyl; bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks and postoperative pain in patients undergoing lumbar disk herniation surgery.

Full description

• Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks in patients undergoing lumbar disk herniation surgery
• Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on postoperative pain in patients undergoing lumbar disk herniation surgery
• Comparison three methods of intrathecal bupivacaine;bupivacaine-fentanyl;bupivacaine-fentanyl-magnesium sulfate on postoperative side effects in patients undergoing lumbar disk herniation surgery

Enrollment: 105 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Candidate for lumbar disk herniation surgery
• No contraindication to the spinal anesthesia
• No history of allergy to opioids and magnesium sulfate
• No peripheral or central neuropathies
• No previous history of surgery on same disk level

Exclusion criteria

• Patients with intraoperative tearing of dural suc
• Occuring of inadvertent intraoperative complications such as bleeding

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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105 participants in 3 patient groups

Magnesium

Active Comparator group

Description:

Patients in group C received a premixed solution of 15 mg hyperbaric bupivacaine 0.5% (3 ml) and 25 µg fentanyl (0.5cc) and 50 mg of magnesium sulfate 50% (0.1 ml) (Pasteur Institute Co, Tehran, Iran) for spinal anesthesia

Treatment:

Drug: Bupivacaine

Drug: Magnesium Sulfate

Procedure: Spinal Anesthesia

Drug: Fentanyl

Fentanyl

Active Comparator group

Description:

Patients in Fentanyl group received a premixed solution of of 15 mg hyperbaric bupivacaine 0.5% (3 ml) and 25 µg fentanyl (0.5cc),plus 0.1 cc preservative free 0.9% normal saline for spinal anesthesia

Treatment:

Drug: Bupivacaine

Procedure: Spinal Anesthesia

Drug: Fentanyl

Bupivacaine

Active Comparator group

Description:

Patients in Bupivacaine group(control) received a premixed solution of 15 mg of hyperbaric bupivacaine 0.5% (3 ml), plus 0.6 cc preservative free 0.9% normal saline for spinal anesthesia

Treatment:

Drug: Bupivacaine

Procedure: Spinal Anesthesia