Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients with Obesity

University of Sao Paulo

Status: Enrolling

Conditions: Periodontitis; Obesity

Treatments: Procedure: antimicrobial photodynamic therapy (aPDT); Procedure: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT06073704

Obesity and Periodontitis

Details and patient eligibility

About

The goal of this clinical trial is to compare the effects of adjuvant antimicrobial photodynamic therapy (aPDT) as an adjuvant of scaling and root planing with scaling and root planing alone for periodontal treatment in patients with periodontal disease and obesity. The main question it aims to answer are: Does adjuvant aPDT improves periodontal health? Are there differences in the proteomic profile of gingival fluid after both treatments? Participants will receive scaling and root planing complemented or not by aPDT. Results will be collected after 1, 3, and 6 months. Researchers will compare adjuvant aPDT treatment to regular treatment to see if it promotes reduction in inflammation and improvement in periodontal health.

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obesity (grade II and III classified according to Body Mass Index)
• Periodontitis stage II to IV
• Presence of at least 20 teeth excluding 3rd molars.

Exclusion criteria

• Smokers
• Alcohol or drugs consumption
• Kidney disorders
• Pregnancy or lactation
• Use of antibiotics at the last 30 days
• Use of drugs that alter periodontal structures as phenytoin or ciclosporin
• Periodontal treatment at the last 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Antimicrobial Photodynamic therapy adjunct to scaling and root planing

Experimental group

Description:

Treatment of scaling and root planing followed by antimicrobial photodynamic therapy with methylene blue (100 micrograms/ml) and red laser

Treatment:

Procedure: antimicrobial photodynamic therapy (aPDT)

Control

Active Comparator group

Description:

Treatment of scaling and root planing.

Treatment:

Procedure: Control