Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery

Stanford University

Status and phase: Completed; Phase 4

Conditions: Intraoperative Bleeding

Treatments: Drug: Saline; Drug: 1% lidocaine with epinephrin 1:100,000; Drug: Epinephrin

Study type: Interventional

Funder types: Other

Identifiers

NCT05867342

40274

Details and patient eligibility

About

In endoscopic sinus surgery a clear surgical field of view is a very important aspect for good surgical outcome. This study is to evaluate the preoperative preparation to acquire best surgical field of view by comparing between the use of topical adrenaline and the use of combination of topical adrenaline with infiltration of 1% lidocaine with adrenaline in patients scheduled for endoscopic sinus surgery for rhinosinusitis.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with recurrent acute or chronic rhinosinusitis recalcitrant to medical treatment and scheduled for endoscopic sinus surgery

Exclusion criteria

• Patients who have asymetrical disease on the two sides (Lund Mackay score difference more than 2)
• Patients who have endoscopic sinus surgery for treatment of tumor or disease other than sinusitis
• Patients with underlying uncontrolled hypertension
• Patients with bleeding disorder or are unable to discontinue antiplatelet or anticoagulant before the surgery
• Patients who are allergic to adrenaline or to xylocaine

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Endoscopic sinus surgery

Experimental group

Description:

Participants receive topical 1:1000 epinephrine plus saline in one nostril, and topical 1:1000 epinephrine plus infiltration of 1% lidocaine with 1:100,000 epinephrine in the other nostril, during endoscopic visualization while undergoing Endoscopic sinus surgery (ESS).

Treatment:

Drug: Epinephrin

Drug: Saline

Drug: 1% lidocaine with epinephrin 1:100,000