Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects

Federal University of Paraíba

Status: Unknown

Conditions: Hypertension; Resistant Hypertension

Treatments: Behavioral: Aerobic Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT02670681

0602/14

Details and patient eligibility

About

The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant hypertension. Resistant hypertensives subjects aged 40 to 70, men or women with body mass index lower that 40 kg/m² are recruited and subjected in acute phase in three sessions of aerobic exercise: mild, moderate, high intensity; and session control. After, the subjects will be randomly allocated into four intervention groups: mild intensity group, moderate intensity group, high intensity group and control group. In both phases, the subjects have blood pressure data recorded by ambulatory blood pressure monitoring, for clinic and ambulatory analysis. In addition, continuously be registered biological signs of blood pressure (finometer), electrocardiogram (DII derivation) and blood flow (venous occlusion plethysmography) for analysis of cardiac autonomic modulation, vascular autonomic modulation, baroreflex sensitivity, vasodilator response and peripheral vascular resistance.

Enrollment: 100 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 40 and 70 years
• Men or women
• Body mass index under 40 kg / m²
• Able to participate in exercise
• No regular physically active in the last 4 months

Exclusion criteria

• Smoking; with history of ischemic stroke or hemorrhagic; or coronary heart disease; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 3 patient groups

Aerobic Exercise Mild Intensity

Active Comparator group

Description:

The subjects engage in aerobic exercise training (8 weeks) of mild intensity (continuous). The intensity is controlled by a corresponding heart rate at anaerobic threshold.

Treatment:

Behavioral: Aerobic Exercise Training

Aerobic Exercise Moderate Intensity

Active Comparator group

Description:

The subjects engage in aerobic exercise training (8 weeks) of moderate intensity (continuous). The intensity is controlled by a corresponding heart rate between anaerobic threshold and respiratory compensation point.

Treatment:

Behavioral: Aerobic Exercise Training

Aerobic Exercise High Intensity

Active Comparator group

Description:

The subjects engage in aerobic exercise (8 weeks) of high intensity interval training. The intensity is controlled by a corresponding heart rate above respiratory compensation point.

Treatment:

Behavioral: Aerobic Exercise Training