Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Appetitive Behavior; Gender Identity; Lipid Disorder; Transgender; Vascular Stiffness; Blood Pressure; Insulin Sensitivity; Vascular Inflammation

Treatments: Other: No intervention

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04066283

18-2258

Details and patient eligibility

About

This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in younger versus older transgender women (people who were assigned male at birth but whose gender identity is female). Data will also be compared to those from cisgender women and men.

Enrollment: 29 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-40 years old or 50-75 years old
• Identify as a transgender woman
• Have taken estradiol and spironolactone for at least one year
• Currently taking oral or transdermal estradiol

Exclusion criteria

• Don't identify as a transgender woman
• Not currently taking estradiol or spironolactone
• Have been on estradiol and spironolactone for less than one year
• History of orchiectomy
• Current tobacco smoker
• Current illicit drug use
• History of prior or active estrogen-dependent neoplasms
• Acute liver or gallbladder disease
• Venous thromboembolism
• Hypertriglyceridemia >500 mg/dL
• Fasted plasma glucose >7.0 mmol/L or previously treated diabetes
• Resting blood pressure >140/90 mmHg

Trial design

29 participants in 2 patient groups

Older transgender women

Description:

This cohort will consist of transgender women aged 50-75 years old who have taken estradiol and spironolactone for at least one year.

Treatment:

Other: No intervention

Younger transgender women

Description:

This cohort will consist of transgender women aged 18-40 years old who have taken estradiol and spironolactone for at least one year.

Treatment:

Other: No intervention