Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Appetitive Behavior; Gender Identity; Lipid Disorder; Transgender; Vascular Stiffness; Blood Pressure; Vascular Inflammation

Treatments: Other: No intervention

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04237467

19-2323

Details and patient eligibility

About

This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male). Data will also be compared to those from age group-matched transgender women and cisgender women and men.

Enrollment: 16 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-40 years old or 50-75 years old
• Identify as a transgender woman
• Have taken testosterone for at least one year
• Currently taking testosterone parenterally (injections) or transdermally (patches or gels)

Exclusion criteria

• Don't identify as a transgender man
• Not currently taking testosterone
• Have been on testosterone for less than one year
• History of hysterectomy/oophorectomy
• Current tobacco smoker
• Current illicit drug use
• History of prior or active estrogen-dependent neoplasms
• Acute liver or gallbladder disease
• Venous thromboembolism
• Hypertriglyceridemia >500 mg/dL
• Fasted plasma glucose >7.0 mmol/L or previously treated diabetes
• Resting blood pressure >140/90 mmHg

Trial design

16 participants in 2 patient groups

Older transgender men

Description:

This cohort will consist of transgender men aged 50-75 years old who have taken testosterone for at least one year.

Treatment:

Other: No intervention

Younger transgender men

Description:

This cohort will consist of transgender men aged 18-40 years old who have taken testosterone for at least one year.

Treatment:

Other: No intervention