Effects of Alcohol History on Effects of Nitrous Oxide - 9

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders; Alcohol-Related Disorders

Treatments: Drug: 0% N2O and 30% N2O; Drug: 0% N2O and 10% N2O; Drug: 0% N2O and 20% N2O; Drug: 0% N2O and 40% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000257

NIDA-08391-9

R01-08391-9

R01DA008391 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.

Enrollment: 19 patients

Sex: All

Ages: 21 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

19 participants in 2 patient groups

Light drinkers

Active Comparator group

Treatment:

Drug: 0% N2O and 30% N2O

Drug: 0% N2O and 20% N2O

Drug: 0% N2O and 40% N2O

Drug: 0% N2O and 10% N2O

Moderate drinkers

Active Comparator group

Treatment:

Drug: 0% N2O and 30% N2O

Drug: 0% N2O and 20% N2O

Drug: 0% N2O and 40% N2O

Drug: 0% N2O and 10% N2O