Effects of Alcoholic Beverages in Pro-inflammatory and Antioxidant Profile After an Oral Fat Diet

Instituto de Investigación Sanitaria Gregorio Marañón

Status: Completed

Conditions: Alcohol Consumption

Treatments: Other: Oral fat diet plus water with sugar; Other: Oral fat diet plus alcoholic beverages

Study type: Interventional

Funder types: Other

Identifiers

NCT02033174

AlcoholInfl_IiSGM_2000

FIS01/0602 (Other Grant/Funding Number)

Details and patient eligibility

About

Hypothesis: Red wine intake but not other alcoholic beverages together with a fat diet will decrease inflammatory factors and lipid peroxidation and decrease antioxidant capacity in healthy people after a five days period.

Enrollment: 16 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers

Exclusion criteria

• Individuals with a plasma cholesterol level > 220 mg/dl
• Smokers

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

Sugar water first, then alcohol

Other group

Description:

8 participants have received oral fat diet plus water with sugar (equivalent caloric intakes as sugar with water in the control group). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and a daily total amount of 16 g/m2 of alcohol, of different beverages (red wine, vodka, brandy or rum)

Treatment:

Other: Oral fat diet plus water with sugar

Other: Oral fat diet plus alcoholic beverages

Alcohol first then sugar water

Other group

Description:

8 participants have received oral fat diet plus alcoholic beverages (a daily total amount of 16 g/m2 of alcohol, of different beverages : red wine, vodka, brandy or rum). Then they receive the same oral fat-enriched diet (1486 kcal/m2) with 654 kcal/m2 (44%) as fat and water with sugar (equivalent caloric intakes as sugar with water in the control group).

Treatment:

Other: Oral fat diet plus water with sugar

Other: Oral fat diet plus alcoholic beverages