Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

University of Verona

Status and phase: Completed; Phase 4

Conditions: Chronic Heart Failure

Treatments: Drug: allopurinol

Study type: Interventional

Funder types: Other

Identifiers

NCT00477789

802

Details and patient eligibility

About

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic heart failure;
• left ventricular systolic dysfunction (ejection fraction <45%)
• stable clinical conditions in the previous three months
• optimal medical therapy for CHF
• normal sinus rhythm
• written informed consent
• age >18 years

Exclusion criteria

• renal failure (s-creatinine >2.5 mg/dl)
• already on allopurinol
• malignancies
• chronic inflammatory diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind