Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism (AMINOFRUCT)

University of Lausanne (UNIL)

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Fructose+maltodextrin placebo; Dietary Supplement: amino-acid + fructose

Study type: Interventional

Funder types: Other

Identifiers

NCT01119989

protocole 51/10

Details and patient eligibility

About

10 healthy male volunteers will be studied after

• a 6 day weight maintenance, balanced diet
• a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day
• a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained
• intrahepatic lipids (1H-MRS)
• metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study

Enrollment: 9 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18-30 years
• sex: males
• BMI between 19 and 25 kg/m2
• less than 3 30min- exercise session/week

Exclusion criteria

• smokers
• alcohol consumption more than 50g/week
• consumption of drugs
• history of diabetes in first degree relatives
• presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Triple Blind

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9 participants in 3 patient groups, including a placebo group

weight maintenance diet

No Intervention group

weight maintenance + fructose

Placebo Comparator group

Treatment:

Dietary Supplement: Fructose+maltodextrin placebo

weight maintenance diet + fructose and amino-acid

Experimental group

Treatment:

Dietary Supplement: amino-acid + fructose