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Effects of Anesthesia on Immunity in Cancer

M

Meshalkin Research Institute of Pathology of Circulation

Status and phase

Completed
Phase 4

Conditions

Surgery
Renal Cancer

Treatments

Drug: Sevoflurane
Procedure: Epidural block
Drug: Propofol

Study type

Interventional

Funder types

NETWORK

Identifiers

Details and patient eligibility

About

The aim of the study is a comparative study of the cellular immunity response of patients operated on for kidney cancer under total intravenous and inhalational anesthesia.

Full description

The severity of perioperative immunosuppression is directly proportional to the degree of surgical stress. A series of experimental and clinical studies indicate a different effect of certain types of anesthesia on immunity. It is believed that surgical stress itself opens an opportunity for the recurrence of oncological diseases precisely due to the immunosuppressive effect. The aim of present pilot clinical study is to test a hypothesis that total intravenous anesthesia as superior to inhalational anesthesia in term of its effects on cell immunity among patients with kidney cancer.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Surgery for renal cancer
  • Signed informed concent

Exclusion criteria

  • Propofol or sevoflurane intolerance
  • Contraindications for epidural anesthesia
  • Renal failure
  • Hepatic failure
  • Congestive heart failure
  • Previous hemotherapy
  • Hematological diseases

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

total intravenous anesthesia
Experimental group
Description:
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and propofol for perioperative anesthesia
Treatment:
Drug: Propofol
Procedure: Epidural block
Volatile anesthesia
Active Comparator group
Description:
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and sevoflurane for perioperative anesthesia
Treatment:
Drug: Sevoflurane
Procedure: Epidural block

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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