Effects of Anesthesia on Immunity in Cancer

Meshalkin Research Institute of Pathology of Circulation

Status and phase: Completed; Phase 4

Conditions: Surgery; Renal Cancer

Treatments: Drug: Sevoflurane; Procedure: Epidural block; Drug: Propofol

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT03514550

Onko1

Details and patient eligibility

About

The aim of the study is a comparative study of the cellular immunity response of patients operated on for kidney cancer under total intravenous and inhalational anesthesia.

Full description

The severity of perioperative immunosuppression is directly proportional to the degree of surgical stress. A series of experimental and clinical studies indicate a different effect of certain types of anesthesia on immunity. It is believed that surgical stress itself opens an opportunity for the recurrence of oncological diseases precisely due to the immunosuppressive effect. The aim of present pilot clinical study is to test a hypothesis that total intravenous anesthesia as superior to inhalational anesthesia in term of its effects on cell immunity among patients with kidney cancer.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Surgery for renal cancer
• Signed informed concent

Exclusion criteria

• Propofol or sevoflurane intolerance
• Contraindications for epidural anesthesia
• Renal failure
• Hepatic failure
• Congestive heart failure
• Previous hemotherapy
• Hematological diseases

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

total intravenous anesthesia

Experimental group

Description:

Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and propofol for perioperative anesthesia

Treatment:

Drug: Propofol

Procedure: Epidural block

Volatile anesthesia

Active Comparator group

Description:

Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and sevoflurane for perioperative anesthesia

Treatment:

Drug: Sevoflurane

Procedure: Epidural block