Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Centre Hospitalier Universitaire Saint Pierre

Status and phase: Completed; Phase 4

Conditions: Obesity; Anesthesia

Treatments: Drug: Propofol; Drug: Desflurane Inhalant Product

Study type: Interventional

Funder types: Other

Identifiers

NCT03417518

B076201420067

Details and patient eligibility

About

Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.

Full description

Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.

Enrollment: 40 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body Mass Index (BMI) >35
• scheduled gastric by pass surgery
• American Society of Anesthesiologists (ASA) <III

Exclusion criteria

• Allergic to anesthesia agent
• patient refusal

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Desflurane Inhalant Product Group

Active Comparator group

Description:

general anesthesia with desflurane

Treatment:

Drug: Desflurane Inhalant Product

Propofol Group

Experimental group

Description:

general anesthesia with propofol

Treatment:

Drug: Propofol