Effects of Anesthetic Techniques on Renal Function

Huiying Shao

Status: Completed

Conditions: Acute Kidney Injury; Congenital Heart Disease

Treatments: Other: inhalation anesthesia; Other: Total intravenous anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT04030481

DEOTATORFDTPPOCSIC

Details and patient eligibility

About

This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Full description

Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Enrollment: 60 patients

Sex: All

Ages: 1 minute to 3 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children with congenital heart disease
• <3 years of age

Exclusion criteria

• preoperative renal insufficiency;
• renal malformation, kidney absence

Trial design

60 participants in 2 patient groups

Group A: Sevoflurane, sufentanil and rocuronium

Description:

sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required

Treatment:

Other: inhalation anesthesia

Group B: Propofol, sufentanil and rocuronium

Description:

propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required

Treatment:

Other: Total intravenous anesthesia