Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Tao Zhang

Status and phase: Completed; Phase 4

Conditions: Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities; Endovascular Repair of Aortic Aneurysm

Treatments: Drug: Propofol; Drug: Remifentanil; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02107170

VIAEV

Details and patient eligibility

About

Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.

Enrollment: 68 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-100 years of age
• Patients presenting for Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities

Exclusion criteria

• Patients with pre-existing delirium
• Inablility to converse

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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68 participants in 2 patient groups

Sevoflurane & remifentanil

Experimental group

Description:

sevoflurane at 0.5 to 1.5 minimum alveolar concentrations plus remifentanil (0.1 - 0.5 µg/kg/min) during the surgery.

Treatment:

Drug: Remifentanil

Drug: Sevoflurane

propofol & remifentanil

Active Comparator group

Description:

propofol (50 - 150 µg/kg/min) plus remifentanil (0.1 - 0.5 µg/kg/min) during the surgery.

Treatment:

Drug: Propofol

Drug: Remifentanil