Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function

Peking University

Status: Unknown

Conditions: Cardiac Toxicity; VEGF; Endothelial Dysfunction

Treatments: Drug: Anti-VEGF

Study type: Observational

Funder types: Other

Identifiers

NCT04962438

Cardiac safety

Details and patient eligibility

About

Explore the effects of anti-VEGF targeted drugs on blood pressure and endothelial function in cancer patients.

Full description

Thirty tumor patients with anti-VEGF drugs were selected. Demographic information and clinical information of all patients were collected before chemotherapy. Ambulatory blood pressure monitoring and endothelial function measurement (PWV, EndoPAT) were performed. Ambulatory blood pressure and PWV were reviewed at 2 weeks and 1 month. And EndoPAT, to evaluate the effects of anti-VEGF drugs on blood pressure and endothelial function in cancer patients.

Enrollment: 30 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Tumor patients using anti-VEGF drugs

Exclusion criteria

• Hypertension, coronary heart disease, valvular heart disease, cardiomyopathy and other organic heart diseases, exclude liver and kidney failure, severe cerebrovascular disease, chronic obstructive pulmonary disease, rheumatic immune system disease

Trial design

30 participants in 1 patient group

Tumor patients using anti-VEGF drugs

Treatment:

Drug: Anti-VEGF