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Effects of Asymmetries on Binaural-Hearing Abilities Across the Lifespan

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University of Maryland

Status

Invitation-only

Conditions

Aging
Hearing Loss
Hearing Asymmetry

Treatments

Diagnostic Test: Test of hearing function

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT06953700
1959852
1R21DC021825 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Binaural hearing involves combining auditory information across the ears. With binaural hearing, listeners benefit from perceiving sounds from different spatial locations. This is critical in solving the "cocktail party problem" (i.e., understanding speech in the presence of competing background sounds and noise). As humans get older, hearing loss increases, binaural abilities decrease, and the cocktail party problem becomes increasingly difficult. This research studies the mechanisms underlying the impact of age and hearing loss on speech-perception in noise and cocktail-party listening situations. More specifically, the role of hearing asymmetries between the ears is investigated. The specific aims are to generate an audiological and binaural-hearing-focused dataset for a large cohort of participants that vary in hearing asymmetry, age, and hearing loss and to use machine learning to uncover complex associations and generate novel hypotheses relating audiometric variables and basic binaural-hearing abilities to the cocktail-party problem. Participants in this research will complete perceptual measures of hearing acuity and spatial hearing. Participants will also report on speech understanding under noisy and challenging listening conditions. This research may lead to improvements in audiological care and hearing interventions.

Enrollment

150 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adults (18-80 years)
  • No hearing asymmetry between ears (≤10 dB at any frequency) or, hearing asymmetry between ears >10 dB
  • Native English speakers
  • Primarily use oral language
  • Sufficient corrected or uncorrected visual acuity (20/50 or better) to read large-font text

Exclusion criteria

  • Acoustic tone-detection threshold >50 dB HL at any octave frequency (250-4000 Hz) in either ear (i.e., more than a moderate hearing loss)
  • History of neurological disorders (e.g., stroke, Parkinson's disease) determined by self-report
  • History of post-traumatic stress disorder or traumatic brain injury determined by self-report
  • Possibility of acoustic neuroma, hearing asymmetry (>10 dB at three consecutive audiometric threshold frequencies)
  • Montreal Cognitive Assessment (MoCA) score <22/30
  • No oral language use
  • Cochlear implant user
  • Conductive hearing loss

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

150 participants in 1 patient group

Test of Hearing Function in Acoustic Hearing Listeners
Experimental group
Treatment:
Diagnostic Test: Test of hearing function

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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