Effects of Atorvastatin on Blood Pressure and Urinary Albumin Excretion

Aristotle University Of Thessaloniki

Status: Completed

Conditions: Hypertension; Hypercholesterolemia

Treatments: Drug: Placebo; Drug: Atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01126684

STAY

Details and patient eligibility

About

To evaluate the possible effects of atorvastatin on ambulatory blood pressure, urinary albumin excretion, insulin resistance and arterial stiffness in hypertensive patients, beyond those on lipid profile. Glycemic parameters, "novel" cardiovascular risk factors and safety parameters will be also evaluated.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• LDL-C>130 or >160 mg/dL (depending on the total risk according to the most recent recommendations25).
• no previous hypolipidemic medication
• ability to provide Informed Consent.

Exclusion criteria

• pregnancy or lactation
• myocardial infarction or unstable angina within the past 6 months
• heart failure NYHA class III-IV
• renal disease (SCr>3 mg/dL or proteinuria>3g/d)
• liver disease
• history of malignancy
• history of drug or alcohol abuse
• treatment with corticosteroids
• any other condition with poor prognosis
• inability to provide Informed Consent.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

Atorvastatin

Active Comparator group

Treatment:

Drug: Atorvastatin

Placebo

Placebo Comparator group

Treatment:

Drug: Placebo