Effects of Augmented Renal Clearance on Pharmacokinetic and Pharmacodynamic Properties of Levetiracetam in Subarachnoid Hemorrhage

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Subarachnoid Hemorrhage

Treatments: Other: Pharmacokinetic modeling

Study type: Observational

Funder types: Other

Identifiers

NCT02866877

15-1823

Details and patient eligibility

About

This study evaluates the pharmacokinetic profile of levetiracetam in critically ill patients who have suffered a subarachnoid hemorrhage. The patients will be evaluated for development of augmented renal clearance and the effects and duration of effects this may have on levetiracetam clearance.

Enrollment: 15 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed with non-traumatic subarachnoid hemorrhage requiring levetiracetam for seizure prophylaxis or treatment
• Presentation to University of Colorado Hospital within 48 hours of subarachnoid hemorrhage
• Adults ages 18 to 89 years
• Anticipated length of stay ≥ 48 hours
• Informed consent provided by the patient or patient's designated medical proxy

Exclusion criteria

• Pregnancy
• Patients receiving renal replacement therapy
• Brain death or imminent brain death expected ≤48 hours
• Patient with history of nephrectomy or renal transplant

Trial design

15 participants in 1 patient group

Subarachnoid Hemorrhage

Treatment:

Other: Pharmacokinetic modeling