Effects of Berries on Post-meal Blood Sugar (SOMA)

Marjukka Kolehmainen

Status: Completed

Conditions: Blood Insulin, Postprandial; Hyperglycemia; Blood Glucose, Postprandial

Treatments: Other: No berries; Other: Berries

Study type: Interventional

Funder types: Other

Identifiers

NCT01580150

70035/09, 1087/31/2009 (Other Grant/Funding Number)

247032

Details and patient eligibility

About

The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

Full description

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

• Studies 1-2: white wheat bread (starch) is consumed with several berry species
• Study 3: white wheat bread or rye bread is consumed with a mixture of berries
• Study 4: sugar (sucrose) is consumed with berries and berry nectars
• Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Enrollment: 20 patients

Sex

Ages: 25 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 20-28 kg/m2
• normal fasting plasma glucose

Exclusion criteria

• Smoking
• Diabetes or other chronic disease
• Antibiotic medication within the past 3 months
• Blood donation within the past month

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Berry meal

Experimental group

Description:

Carbohydrate meals with berries

Treatment:

Other: Berries

Reference meal

Active Comparator group

Description:

Carbohydrate meals without berries

Treatment:

Other: No berries