Effects of Betaine Supplementation on Strength and Muscle Creatine Content

University of Sao Paulo

Status: Completed

Conditions: Healthy Subjects

Treatments: Dietary Supplement: betaine; Dietary Supplement: creatine; Dietary Supplement: creatine plus betaine; Dietary Supplement: dextrose

Study type: Interventional

Funder types: Other

Identifiers

NCT01213719

betaine supplementation

Details and patient eligibility

About

It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Enrollment: 40 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• physically inactive
• non-obese

Exclusion criteria

• skeletal muscle disturbance
• cardiovascular disturbance
• use of dietary supplements

Trial design

40 participants in 4 patient groups, including a placebo group

creatine

Experimental group

Description:

will receive creatine monohydrate (20g/d) throughout 10 days

Treatment:

Dietary Supplement: creatine

betaine

Experimental group

Description:

will receive betaine (2g/d) throughout 10 days

Treatment:

Dietary Supplement: betaine

placebo (dextrose)

Placebo Comparator group

Description:

will receive dextrose(20g/d)throughout 10 days.

Treatment:

Dietary Supplement: dextrose

creatine plus betaine

Active Comparator group

Description:

will receive creatine (20g/d) plus betaine (2g/d) throughout 10 days

Treatment:

Dietary Supplement: creatine plus betaine