Effects of BFR Interventions in Healthy Individuals and Individuals With COPD

Morten Hostrup, PhD

Status: Enrolling

Conditions: Healthy; COPD

Treatments: Other: BFR during training; Other: BFR during rest

Study type: Interventional

Funder types: Other

Identifiers

NCT05734534

BFR

Details and patient eligibility

About

The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.

Enrollment: 105 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for participants with COPD group are:

• Diagnosis with COPD

Exclusion criteria participants in the COPD group are

• Having experienced an acute exacerbation of COPD within the last 6 weeks (Study A)
• Taking part in pulmonary rehabilitation within the last 3 months (Study A)
• Presenting with a history of thromboembolic event in the lower limbs.

Inclusion criteria for healthy participants are:

• Age between 18 and 40 years.
• Maximal oxygen uptake (VO2max) of >55 ml O2/kg/min for men and >50 ml O2/kg/min for women
• BMI of <26 and normal ECG and blood pressure.

Exclusion criteria for healthy participants are:

• Smoking
• chronic disease,
• Use of prescription medication
• Pain due to current or previous musculoskeletal injury
• Resistance training more than once per week in the 12 months leading up to the intervention.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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105 participants in 5 patient groups

BFR-ST and BFR-HIT

Experimental group

Description:

Participants will be allocated to a BFR intervention including resistance training and high-intensity intervals performed on a bicycle ergometer, both performed with BFR.

Treatment:

Other: BFR during training

HL-ST and HIT

Active Comparator group

Description:

Participants will be allocated to heavy load resistance training and high-intensity intervals performed on a bicycle ergometer, both performed without BFR

Treatment:

Other: BFR during training

BFR-P

Experimental group

Description:

Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR.

Treatment:

Other: BFR during rest

BFR-NMES

Experimental group

Description:

Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR with neuromuscular electrical stimulation (BFR-NMES) twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR-NMES.

Treatment:

Other: BFR during rest

Control group

Active Comparator group

Description:

Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will allocated to usual care, consisting of daily physiotherapy sessions.

Treatment:

Other: BFR during rest