Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.

Riphah International University

Status: Enrolling

Conditions: Mild Cognitive Impairment

Treatments: Other: Combined Cognitive & Aerobics Training; Other: Cognitive Training

Study type: Interventional

Funder types: Other

Identifiers

NCT06867016

REC/MS-PT/O2029 Saliha Ashfaq

Details and patient eligibility

About

The study aims to assess the effects of Bidomain cognitive and aerobic training on both cognitive functioning and quality of life in individuals with mild cognitive impairment.

Full description

The proposed study addresses a notable gap in the literature regarding the comparison between combined cognitive-aerobic training and cognitive training alone in improving cognitive function for patients with mild cognitive impairment (MCI). While previous studies have demonstrated the positive effects of both training methods on cognitive function independently, there is currently no research directly comparing their effectiveness when used together. The study aims to provide evidence on which treatment regime-combined cognitive-aerobic training or cognitive training alone-offers better outcomes for MCI patients. Aerobic training is known to enhance brain structure and function by strengthening neuronal connections, largely due to increased levels of brain-derived neurotrophic factor (BDNF) and enhanced vascularization, which stimulates hippocampal growth. On the other hand, cognitive training improves global cerebral functional connectivity, particularly activating the prefrontal cortex, which leads to better cognitive performance. Combining these training modalities may yield greater benefits than focusing on just one, offering a cost-effective, accessible approach that could significantly improve the quality of life and daily functioning for individuals with MCI.

Enrollment: 44 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Older adults 60 years & above
• With normal vision and color perception
• Independent Individual capable of carrying out daily tasks
• Individuals scoring 21-25 on the Mini-Mental State Examination (MMSE)

Exclusion criteria

• Medication affecting the exercise capacity of individual
• Regular participation in aerobic training for the last six months
• Cardiovascular or other diseases that do not allow physical activity
• A diagnosed severe psychiatric disease (e.g., depression)
• Patients with cognitive impairment or other neurological impairments due to AD or dementia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 2 patient groups

Combined Cognitive & Aerobic Training Group

Experimental group

Description:

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format.

Treatment:

Other: Combined Cognitive & Aerobics Training

Cognitive Training Group

Active Comparator group

Description:

Cognitive training group include cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises.

Treatment:

Other: Cognitive Training