Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals

Wecare Probiotics

Status: Enrolling

Conditions: Healthy Individuals

Treatments: Dietary Supplement: Placebo; Dietary Supplement: LRa05; Dietary Supplement: BLa80

Study type: Interventional

Funder types: Industry

Identifiers

NCT07287306

WK20251120

Details and patient eligibility

About

Gut microbiota play a key role in polyphenol metabolism, participating in the breakdown of dietary components and producing various small molecule metabolites that affect human health. However, little is currently known about how gut microbes metabolize dietary compounds and produce bioactive metabolites. This study aims to use metabolomics to precisely identify food-derived metabolites in the blood to investigate whether probiotics (BLa80, LRa05) can enhance the breakdown of dietary components and improve their absorption and utilization in the human body.

Enrollment: 375 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male or female participants aged 18 to 60 years;
2. Healthy individuals;
3. Participants must provide written informed consent.

Exclusion criteria

1. History of gastrointestinal surgery, other gastrointestinal diseases, metabolic disorders, immunodeficiency, hyperthyroidism, or cardiac or liver disease;
2. Use of immunosuppressants;
3. Pregnant or breastfeeding women;
4. Participants who have taken antibiotics or probiotics within the previous 3 months;
5. Planned surgery during the study period;
6. Patients with neurological disorders or psychiatric illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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375 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Each placebo stick contained 3 g of dextrin. Dosage: one stick per day.

Treatment:

Dietary Supplement: Placebo

BLa80

Experimental group

Description:

Each probiotic stick contained dextrin and 2 × 10¹⁰ CFU BLa80. Dosage: one stick per day.

Treatment:

Dietary Supplement: BLa80

LRa05

Experimental group

Description:

Each probiotic stick contained dextrin and 2 × 10¹⁰ CFU LRa05. Dosage: one stick per day.

Treatment:

Dietary Supplement: LRa05