Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People

University of Exeter

Status: Completed

Conditions: Cognitive Aging

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Blueberry

Study type: Interventional

Funder types: Other

Identifiers

NCT02985580

1314/134617

Details and patient eligibility

About

Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.

Enrollment: 26 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 60-80y
• Addenbrooke's Cognitive Examination III questionnaire > 88
• Consuming 5 or less portions of fruit per day

Exclusion criteria

Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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26 participants in 2 patient groups, including a placebo group

Blueberry

Active Comparator group

Description:

Blueberry concentrate consumed daily for 12 weeks.

Treatment:

Dietary Supplement: Blueberry

Placebo

Placebo Comparator group

Description:

Placebo concentrate consumed daily for 12 weeks.

Treatment:

Dietary Supplement: Placebo