Effects of Blueberry-polyphenols on Endothelial Function, Absorption and Metabolism

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Placebo Group; Dietary Supplement: Blueberry Group

Study type: Interventional

Funder types: Other

Identifiers

NCT02520830

Blueberries

Details and patient eligibility

About

Diets rich in fruits and vegetables have been linked to favorable cardiovascular outcomes in epidemiological studies.

Dietary intervention studies with certain micronutrients have shown promising effects on surrogate parameters of vascular risk including blood pressure, endothelial function and cholesterol levels. Wild blueberries have gained attention due to their high content of phytochemicals and particularly anthocyanins. Whether wild blueberries can improve vascular function and health when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of wild blueberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk.

Enrollment: 45 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male subjects without clinical signs or symptoms of cardiovascular disease
• 18-70 years

Exclusion criteria

• cardiovascular disease
• acute inflammation
• cardiac arrhythmia
• renal failure
• heart failure (NYHA II-IV)
• diabetes mellitus
• C- reactive protein > 1mg/dl
• malignant disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 2 patient groups, including a placebo group

Blueberry Group

Active Comparator group

Description:

Dietary Supplement: 22 gram freeze-dried blueberry powder per day

Treatment:

Dietary Supplement: Blueberry Group

Placebo Group

Placebo Comparator group

Description:

blueberry polyphenol deprived powder 22 gram per day

Treatment:

Dietary Supplement: Placebo Group