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Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Elderly Healthy Subjects

Charité University Medicine Berlin logo

Charité University Medicine Berlin

Status

Completed

Conditions

Elderly Subjects

Treatments

Device: Stimulation
Device: SHAM

Study type

Interventional

Funder types

Other

Identifiers

NCT01791790
Nighttime sleep-tSOS-Old

Details and patient eligibility

About

The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. Recent evidence in young healthy subjects suggest that the sleep-associated consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during SWS. If elderly, healthy subjects benefit from transcranial slow oscillatory stimulation (tSOS) during nocturnal sleep as well has not been studied so far. The primary aim of the present study is to investigate the influence of a weak slow oscillating brain stimulation (tSOS) on declarative memory consolidation applied during periods of nocturnal SWS in elderly healthy subjects.

Enrollment

32 patients

Sex

All

Ages

50 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • elederly, healthy Subjects
  • unobtrusive, neuropsychological screening
  • age: 50-90 years
  • right handed

Exclusion criteria

  • untreated severe internal or psychiatric diseases
  • epilepsy
  • other severe neurological diseases eg., previous major stroke, brain tumour, dementia
  • contraindications to MRI

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

32 participants in 2 patient groups

0,75 Hz stimulation
Experimental group
Description:
slow transcranial oscillating stimulation (\~0,75Hz) during periods of Slow Wave Sleep
Treatment:
Device: Stimulation
SHAM stimulation
Sham Comparator group
Description:
SHAM stimulation during periods of Slow Wave Sleep
Treatment:
Device: SHAM

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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