Effects of Calcium and Phytate on Zinc Absorption

USDA Grand Forks Human Nutrition Research Center

Status: Completed

Conditions: Dietary Zinc Absorption

Treatments: Dietary Supplement: High Calcium, High Phytate Diet; Dietary Supplement: Moderate Calcium, Low phytate Diet; Dietary Supplement: High Calcium, Low Phytate Diet; Dietary Supplement: Moderate Calcium, High Phytate Diet

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00754390

GFHNRC042

Details and patient eligibility

About

This study is determine the effects of dietary calcium and phytate on zinc absorption.

Full description

Zinc absorption is tested from 2 days of consuming each of four diets with zinc-65 isotope, followed by retention monitoring in a whole body scintillation counter for 4 weeks. All four 4 experimental diets are tested with each subject, in randomized order, for a total of 16 weeks.

Enrollment: 17 patients

Sex: Female

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Average weight for height

Exclusion criteria

• Medications other than birth control pills or hormone replacement therapy,
• Pregnancy within last 6 months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Overall Study

Experimental group

Description:

Participants consumed 4 experimental diets for 4 weeks each in randomized order

Treatment:

Dietary Supplement: High Calcium, High Phytate Diet

Dietary Supplement: High Calcium, Low Phytate Diet

Dietary Supplement: Moderate Calcium, High Phytate Diet

Dietary Supplement: Moderate Calcium, Low phytate Diet