Effects of Canola Oil and Coconut Oil on Postprandial Metabolism in Older Adults With Increased Cardiometabolic Risk

University of Bonn

Status: Completed

Conditions: Cardiovascular Diseases; Metabolic Syndrome

Treatments: Dietary Supplement: Mixed meals

Study type: Interventional

Funder types: Other

Identifiers

NCT05208346

528/191

Details and patient eligibility

About

The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals on parameters associated with cardiometabolic diseases. Therefore, older subjects with increased risk of cardiometabolic diseases consume 4 mixed meals with 25 or 50 g of either canola or coconut oil. In a postprandial period of 6 hours, outcomes associated with cardiometabolic risk (e.g., triglycerides) are analyzed.

Full description

In a crossover design, 30 older men and women with increased risk of cardiometabolic diseases consume 4 mixed meals, enriched with either 25 or 50 g canola or coconut oil. During a postprandial period of 6 hours, parameters of lipid metabolism (e.g., plasma triglycerides), glucose metabolism (e.g., plasma glucose, serum insulin), as well as markers of inflammation (e.g., IL-6), vascular system (e.g., pulse wave velocity) and antioxidant system (e.g., trolox equivalent antioxidative capacity) are analyzed. Furthermore, fatty acid profile, neuropsychologic parameters (e.g., attention), subjective feeling of hunger and satiety, and satiety-associated hormones (e.g., ghrelin) are assessed. Each intervention arm will be separated by a washout period of about 14 days.

Enrollment: 30 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI: 27 - 34,9 kg/m2
• Waist circumference: women ≥ 80 cm, men ≥ 94 cm
• At least two of the following criteria of metabolic syndrome:

Fasting triglycerides in serum: ≥ 150 mg/dl Fasting HDL-Cholesterol in serum: women < 50 mg/dl, men < 40 mg/dl Systolic blood pressure: ≥ 130 mmHg, diastolic blood pressure: ≥ 85 mmHg Fasting glucose in plasma: ≥ 100 mg/dL

Exclusion criteria

• Smoking
• Diseases that may impact outcome measures (e.g., thyroid diseases, insulin-dependent diabetes mellitus, impaired renal function, tumors, anemia)
• Intake of immunosuppressives or supplements (e.g., fish oil)
• Participation in another study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 4 patient groups

Canola oil high-fat

Experimental group

Description:

Participants randomized to receive a mixed meal with 50 g canola oil

Treatment:

Dietary Supplement: Mixed meals

Coconut oil high-fat

Experimental group

Description:

Participants randomized to receive a mixed meal with 50 g coconut oil

Treatment:

Dietary Supplement: Mixed meals

Canola oil low-fat

Experimental group

Description:

Participants randomized to receive a mixed meal with 25 g canola oil

Treatment:

Dietary Supplement: Mixed meals

Coconut oil low-fat

Experimental group

Description:

Participants randomized to receive a mixed meal with 25 g coconut oil

Treatment:

Dietary Supplement: Mixed meals