Effects of Cerebellum or Supplementary Motor Area Functional Inactivation on Gait and Balance Control (CERESMARCHE)

Institut National de la Santé Et de la Recherche Médicale, France

Status and phase: Completed; Phase 2; Phase 1

Conditions: Transcranial Magnetic Stimulation

Treatments: Other: transcranial magnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02976298

2012-A00796-37 (Registry Identifier)

C12-05

Details and patient eligibility

About

In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have been identified as involved in such control. The specific role of these structures in both the capacity to go forward (locomotion) and stand upright (balance), but also in the different phases of the gait initiation process, are not known, however. In this study,the investigators aimed to assess the specific role of both the supplementary motor area (SMA) and the cerebellum in postural control during the initiation of gait. For this purpose, the investigators plan to study the gait initiation in 20 healthy subjects before and after functional inactivation (using inhibitory repetitive transcranial magnetic stimulation, rTMS) of the cerebellum or SMA. Biomechanical, kinematic and electromyographic parameters of the gait initiation will be recorded using a force platform, reflective markers with infrared cameras (VICON system) and lower limbs surface EMG electrodes.

Enrollment: 20 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-70 years
• agree to participate to the study with signature of the informed consent
• heathy insurance
• normal clinical exam

Exclusion criteria

• previous medical history of neurological, rheumatological, orthopedic or psychiatric disorders
• contra-indication to MRI or TMS
• drug treatment that modifies the nervous central system excitability (antidepressant, antiepileptic, neuroleptic)
• chronic alcoholism

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 3 patient groups

transcranial magnetic stimulation

Sham Comparator group

Description:

sham transcranial magnetic stimulation

Treatment:

Other: transcranial magnetic stimulation

supplementary motor area stimulation

Experimental group

Description:

supplementary motor area transcranial magnetic stimulation

Treatment:

Other: transcranial magnetic stimulation

cerebellar stimulation

Experimental group

Description:

cerebellar transcranial magnetic stimulation

Treatment:

Other: transcranial magnetic stimulation