Effects of Chemotherapy on Muscle Mass and Exercise Performance in Patients With Oesophageal Cancer. (Oeso-Chemo)

University of Nottingham

Status: Completed

Conditions: Oesophageal Adenocarcinoma

Treatments: Procedure: Muscle biopsy; Radiation: DEXA scan; Other: cardio-pulmonary exercise testing (CPEX)

Study type: Observational

Funder types: Other

Identifiers

NCT01742312

10/H0405/38

Details and patient eligibility

About

Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.

Full description

We aim to review the effects of chemotherapy on skeletal muscle mass and cardio-respiratory performance in patients with oesophageal adenocarcinoma. All patients will be assessed by a Consultant Anaesthetist and a medical member of the Research team before commencing chemotherapy and after finishing their course. These assessments include a nutritional assessment, performance status assessments, blood assays, dual energy X-ray absorptiometry (DEXA) scans, cardio-pulmonary exercise (CPEX) testing and a muscle biopsy.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• oesophageal cancer
• Multidisciplinary team decision to offer neoadjuvant chemotherapy prior to surgery

Exclusion criteria

• Metastatic disease

Trial design

25 participants in 1 patient group

oesophageal adenocarcinoma

Description:

DEXA scan cardio-pulmonary exercise testing (CPEX) muscle biopsy

Treatment:

Other: cardio-pulmonary exercise testing (CPEX)

Radiation: DEXA scan

Procedure: Muscle biopsy