Effects of Chestnuts on Postprandial Glycaemic Response

Monash University

Status: Not yet enrolling

Conditions: Insulin Resistance; Postprandial Glycemia

Treatments: Other: Chestnut meal; Other: Control meal

Study type: Interventional

Funder types: Other

Identifiers

NCT06960967

ChestnutsProject

Details and patient eligibility

About

Nut consumption is known to improve health outcomes, such as reducing the risk of chronic diseases like diabetes, cognitive impairment, and cardiovascular diseases. While most research has focused on walnuts and almonds, there is limited information on the health benefits of chestnuts. Chestnuts are unique among tree nuts due to their high starch and fibre content, along with vitamins E and C, minerals (potassium, phosphorus, magnesium), and polyphenols.

Evidence from in vitro and animal studies suggests that chestnuts may positively affect health by regulating the gut microbiome, lowering the glycaemic index, and providing antioxidant benefits. The food industry is also exploring new uses for chestnuts, particularly in gluten-free products, due to their nutritional benefits and good taste. Nonetheless, no research has investigated the health effects of chestnuts in humans. By addressing this gap in the literature, the study may lead to the development of new dietary strategies for improved health outcomes.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults 18-65 years old
• Available to attend two testing sessions at the research facility

Exclusion criteria

• Allergy to nuts and/or gluten,
• BMI<18.5 or ≥30 kg/m2,
• Fasting glucose >5.6 mmol/L, presence of diabetes and/or taking anti-diabetic medication
• Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery,
• Smoker,
• Cardiovascular disease
• Pregnant or breastfeeding women
• Presence of implanted cardiac defibrillator

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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15 participants in 2 patient groups, including a placebo group

Control meal

Placebo Comparator group

Description:

Participants will receive an isocaloric baked meal without chestnut flour.

Treatment:

Other: Control meal

Chestnut meal

Experimental group

Description:

Participants will receive an isocaloric baked meal with chestnut flour.

Treatment:

Other: Chestnut meal