Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa

Aydin Adnan Menderes University

Status and phase: Not yet enrolling; Phase 4

Conditions: Oral Mucosal Disorder

Treatments: Drug: Control 1

Study type: Interventional

Funder types: Other

Identifiers

NCT06942026

1758-1738-28-08-2024

Details and patient eligibility

About

The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa. In addition, the investigators will learn about the safety of ozonated water and hypochlorous acid solution. The main questions that participants need to answer are:

What medical conditions do participants have while taking ozonated water and hypochlorous acid solution?

Investigators will compare ozonated water and hypochlorous acid solution with 0.12% chlorhexidine gluconate solution to see if it helps to restore the integrity of the oral mucosa.

Participants:

Participants will be asked to agree to receive oral care 4 times a day, every day for 1 week.

Enrollment: 63 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be between the ages of 18-65,
• Have been on mechanical ventilation for at least 24 hours,
• Have no intolerance or allergy to the solutions,
• Agree to participate in the study

Exclusion criteria

• Having a contraindication for oral care
• Not agreeing to participate in the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

63 participants in 3 patient groups

Experimental 1

Experimental group

Description:

Ozonated water

Treatment:

Drug: Control 1

Experimental 2

Experimental group

Description:

hypochlorous acid

Treatment:

Drug: Control 1

Control 1

Active Comparator group

Description:

%0.12 chlorhexidine gluconate

Treatment:

Drug: Control 1